The purpose of this study was to evaluate the potential for buccal sustained delivery of metronidazole. Metronidazole was choosen as model drug with an aim to develop buccal drug delivery system having characteristics like; small size, flexibility & adaptability to the mucosa, no irritation, and no discomfort as well as to develop a sustained release system for 12 hrs. Direct compression method was used for preparation of buccal tablets. All the ingredients were weighed accurately and mixed by geometrical dilution method in a mortar with pestle to prepare a homogeneous powder mixture. Then the powder mixture was directly compressed to prepare tablet using 10 mm punch in Single punch rotary press. The prepare formulation were evaluated for various parameters like hardness, thickness, average weight, swelling index, surface pH, mucoadhesive strength, drug content, % cumulative drug release. The optimized formulation was subjected to stability study for 1 month. In preliminary batches 3 polymers were used in combinations, from the obtained evaluation data of preliminary batches polymers (Carbopol 934 P and NaCMC) were selected for further factorial design batches, from the evaluation parameters data, it had been seen that the Batch F6 Showed good results from all batches. Batch F6 show hardness 3.82 kg/cm2, thickness 1.69 mm, friability 0.32%, surface pH 6.42, average weight 124.5 mg, mucoadhesive strength 31.8 gm and drug content 98.45%. It also gives maximum drug release up to 97.306 % in 12 hrs from all other batches.
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